A scramjet stage will be very light compared to an equivalent rocket stage, since it carries only the energy source (fuel) and not the full reaction mass. If this scramjet stage is able to impart a velocity close to the orbital velocity by the time it reaches the upper atmosphere, the subsequent rocket stage will have much less work to do to get it into orbit. And that translates to much less propellants (including oxidizer) and much less mass in the upper stage. It's not necessary to collect oxygen from the atmosphere to see an advantage.
Obviously, the raising of the perigee at apogee is going to need this rocket engine again. There are no launcher concepts that depend purely on scramjets.
Minimizing fueled mass of the vehicle is a stupid thing to do. It's optimizing the wrong metric.
Scramjets also suffer from bad thrust/mass and thrust/$ ratios compared to rocket engines.
Overall scramjet launch vehicles are an example of pyrrhic engineering: even if one could make such a vehicle "work", no one would want it.
Its not the cost, its the mass you're trying to reduce. So far, the engineering challenges have made it unfeasible, but its not a surprise that people look at the hundred tons of LOX on a rocket and imagine exchanging it for payload (or aircraft style re-usability).