I agree that it may be best to avoid needing the space and facilities for a human being in the satellite. Fire and forget. Launch it further into space instead of back to earth for a decommission. People can salvage the materials later.
This effect can be somehow overcome by exercising while in space but it's not perfect even with the insane amount of medical monitoring the guys up there receive.
It's theoretically possible for sure, but we've never done that in practice and it's far from trivial.