If you run amiss of US (or EU) regulators, they will never say, "well, it's in space, out of our jurisdiction!".
They will make your life hell on Earth.
If you want permissive regulatory environment, just spend the money buying a Mercedes for some politician in a corrupt country, you'll get a lot further...
Which is a good analogy; international waters are far from lawless.
You're still subject to the law of your flag state, just as if you were on their territory. In addition to that, you're subject to everyone's jurisdiction if you commit certain crimes - including piracy. https://en.wikipedia.org/wiki/Universal_jurisdiction