https://www.clockworkpi.com/uconsole
I have a couple of these - they work great for dev systems and its occasionally fun to load up PICO8 and have a bit of a bash..
I also have a couple of OpenPandora's but I stopped using them when I got a Steam Deck.
I had previously experimented with the CM5, and found out that you can't really use it for anything portable without attaching a heavy battery. With its excellent software stack, CM5 could have been everywhere if they had gotten this right.
Another comment mentions the RP2xxx microcontrollers. If you look at those, they are optimised for compute power and data throughput rather than low power operation. I think it's a reasonable choice - the Pico boards are pretty sturdy and the original target is people running MicroPython, Arduino, etc rather than looking for µA standby currents.