Without that your options for HA shared storage is Ceph (which proxmox makes decently easy to run), or NFS.
1. Proxmox cannot even join a network using DHCP requiring manual IP configuration.
2. Disk encryption is a hell instead of checkbox in installer
3. Wi-Fi - no luck (rarely used for real servers, but frequently for r&d racks)
Of course, it is a Debian core underneath and a lot of things are possible given enough time and persistence, but other solutions have them out of the box.
Yes, Proxmox is built on Debian so anything Debian can do Proxmox VE can mostly do as well without major issues.
FWIW, I use Proxmox at home. It’s a bit obtuse at times, but it runs like a champ on my N100-based NUCs.