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I completely agree my mother has MS and I have my own autoimmune issues. Something like this would be extremely helpful for people with debilitating diseases that cause muscle deterioration.
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Maybe you can checkout the Dephy Exoboot: https://www.dephy.com No idea how far along they are though, but looks like they are open for early access.

I'm sure you've already seen https://eu.hypershell.tech

I'm hopeful these get cheaper, smaller and lighter, and more powerful. Would be great to have these accessible to a lot of people.

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Wow, that's awful. Have you looked into the existing powered exoskeletons? Or are those too hip/thigh focused to help?
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There's some excellent knee ones, too
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Are you using something like this? Do you get back most of your previous functionality?

https://newatlas.com/unpowered-ankle-exoskeleton-walking-eff...

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