Things would be different in a colder climate where humidity goes --> 0% in the winter
It is much cheaper to use external air for cooling if you can.
Also this is where cutting corner indeed results in lower cost, which was the reason for the OP to begin with. It just means you won't get as good a datacenter as people who are actually tuning this whole day and have decades of experience.
RAM that is plugged in and operating isn't subject to external ESD, unless you count lightning strikes. Where are you getting this?