Interstellar space is also hostile to life, and any life present at the destination will not use the same DNA coding for protein (if gene expression even works that way).
We also do not yet have the technology for a complete survey of nearby habitable planets.
It is not an encouraging line of thought.
Everyone you knew on earth would be dead by the time you got back, but if it's just about you, the speed of light is no limitation at all. (The rocket equation, however, presents stupendous engineering challenges.)
The 2020s have not been known as reasons for great optimism. The pandemic and AI culling clades of the job market have been traumatizing experiences.
We don't even know that this isn't a simulation. Not non-falsifiable, sure. But we're convinced we're bound to this solar system with our crude tools and limits of detection.
One new instrument could upset our grand understanding and models. Maybe we should wait until they get better hardware to marry ourselves to their prognostications of the end of time.
During the postwar years of plenty, people stopped dreaming. We had bold dreams before WWII, but people stopped looking at how far we'd come and started comparing themselves to everyone else. We had no mortal enemy, tremendous wealth, and "keeping up with the Joneses" became the new operating protocol.
We have more than we did in the past. The manufacturing wealth of 1940-1970 was a fluke. The trade wealth of 1980-2020 was a fluke. We were upset over an unfair advantage that won't last forever. Even today we're still better off than a hundred years ago, yet everyone focuses on how bad things are.
Maybe a return to hardship will make us dream again.
We don't know why the expansion is accelerating. For that we have only speculation.
Would any of the stories about the characters’ relationships with people not traveling with them be entertaining given the effects of time dilation?
Maybe it's as simple as free societies not having the evolutionary pressure to produce great literature that requires an interested and intelligent reader to decode the hidden messages written between the lines ;)