There are many times where unblinded experiments are still valid. And unfortunately, n=1 means that you can't have controls. The question: "did this intervention, in one person, cause a greater-than-normal increase in epigenetic changes, above baseline?"
I was just listening to something the other day about how there is essentially no way to study this right now, and the most common method of microplastic detection in samples has been proven largely inaccurate.
Is there some reason we think microplastics are more dangerous than the other nanoparticles of inorganic dust we consume and inhale every day? Serious question - I’ve got enough to worry about and this seems… very low on that list?