The Taliban was repeatedly crushed. All of the leadership was killed many times over. The problem is the Taliban is an idea that transcends individual human members and it can always be reconstituted. It also benefited from being able to harbor supporters in Pakistan, which is a nuclear power the US was not willing to also invade.

There isn't a real analogy there because cartel leaders have no official state support anywhere, let alone in a bordering nuclear power, but even if they did, it hardly seems reassuring from their perspective to know the drug trade will outlive them after they all get killed. It's different when you're deeply religious and believe what you're doing is worth dying for and the larger arc of history is more important than your own life and wellbeing. I don't think drug lords think that way.

I don’t think the technology matters nearly as much as the asymmetry. Iraq had better technology than the Taliban and their military didn’t last a week.

I think the key difference between the Taliban and the cartels is that the Taliban were a bunch of ideologues who actually enjoyed being an insurgency and living under siege in caves, with making money from the drugs trade being a mere means to their real purpose of fighting infidels, whereas the cartel leadership sees wealth and power from controlling the drugs trade as an end, crushing local rivals as a means, and would really rather avoid the sort of conflict that's bad for their medium term business prospects.

I mean, some sort of cartels would bounce back after any "war on drugs" because supply and demand, but the people running them aren't hankering for martyrdom or glory over consolidating their territory and accumulating.