The Transputers (mentioned in other comments) had already decoupled the core speed from the bus speed and Chuck Moore got a patent for doing this in his second Forth processor[1], which patent trolls later used to extract money from Intel and others (a little of which went to Chuck and allowed him to design a few more generations of Forth processors).
What is the current best symbol rates we get on PCB traces? I know we’ve been multiplexing a lot of channels using the same tricks we used with modems to get above 9600bps on POTS.