In the parent comment's case of not having other dependencies, whatever the React ecosystem does isn't relevant if you aren't using any React libraries, which aren't really necessary anyways, especially nowadays when the LLM can reimplement what you need for you.
Nothing has changed about react-dom that prevents you from using React piece by piece—its docs still recommend attaching to a #root node even for single page apps.
Including web components in a React app is very seamless, and embedding non-React-controlled elements inside React is not uncommon (e.g. canvas, Monaco, maps), though for common use cases there's usually convenience libraries for React that wrap around these.
React DOM/views have not significantly changed in 12 years.
Our 10 year React projects that used mobx have not changed very much.
Savage take: I found React when it came out and I thought “wow you made this gorgeous DOM library and then you bolted on this messy ugly wart for state.” Then hooks came out and I’m like… this is a good electrician pretending they can also do plumbing.