Mine was assuming that the stripe on tantalum SMD capacitors was the negative side. First prototype board came back from the fab and pick and place department (we had it in house). Immediately caught fire when I powered it up :)
Second lesson, start with current limit on your bench supply, not throw 10A into it :)
Shoutout to OSHpark's prototype service. Something like 5 bucks an inch and you only have to toss out 3 if you find a fault.
Printing the board outline and layers combined as well. And checking you used the correct footprints against actual parts helps.