I live in tourist Prague, pretty much never talking with someone other than when I see someone clearly struggling with directions in public transport and I see they go out of the tourist city center I just confirm whether they know it, most of the time* it's not what they intend to do.
*Germans being the exemption, seems they like to do whole team line grim the end to end to see the city even when it's not touristy, for these I have recommendation of some rare above the ground subway sections