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Anecdotal, but I asked Claude the other day about how to dilute my medication (HCG) and it flat out refused and started lecturing me about abusing drugs.

I copy and pasted into ChatGPT, it told me straight away, and then for a laugh said it was actually a magical weight loss drug that I'd bought off the dark web... And it started giving me advice about unregulated weight loss drugs and how to dose them.

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If you had created a project with custom instructions and/ or custom style I think you could have gotten Claude to respond the way you wanted just fine.
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