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I use GIMP and GrafX2 for my sprite art. The latter being an old-school type program in the tradition of Deluxe Paint.
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GrafX2 looks cool, I'll consider it if I'm doing something specifically for older micros like the amiga
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Aseprite is the best tool for pixel art full stop
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It depends on what you are doing. I really like it for creating animated characters. Resprite has some nice feature for creating tilesets. Standard raster editing software might be better for big static scenes.
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