I used to play fretless bass in a garage hip hop troupe that played with heavily manipulated samples that were all over the place in terms of tuning instead of locked to A440, forcing adaptations like "this section is a minor chord a little above C#".

Adaptive tuning is hard to do on a guitar because the frets are fixed. String bending doesn't help much because the biggest issue is that major thirds are too wide in equal temperament and string bending the third makes pitch go up and exacerbates the problem.

You can do a teeny little bit using lateral pressure (along the string) to move something flat. It's very difficult to make adaptations in chords though. A studio musician trick is to retune the guitar slightly for certain sections, though this can screw with everybody else in the ensemble.

Attempts to experiment with temperament using squiggly frets make it clear how challenging this problem is: https://stringjoy.com/true-temperament-frets-explained/