The E, D and B strings are turned such that they yield clean octaves (and other equal-temperament intervals).
Then so are the A, G and E.
But these two groups are slightly detuned, so that the fifths are clean from the E to A string, D to G, and B to E.
2. The error between the equal temperament perfect fifth and the pure one (3/2) is just less than 2 cents. So the difference I'm talking about is at the same level of accuracy as that of pretty excellent guitar intonation. The corrections are not simply for equal temperament; they are not separable from the condition of the instrument and its intonation. The given instrument is what it is, and to get those 1-5-8 power chords to sound clean you do whatever you have to.