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> The infrastructure to get it that pure becomes very specialized

I think some of the most advanced fab infrastructure is the ultra pure water system. Water becomes quite aggressive chemically when it has no dissolved ions in it. You have to use exotic or highly processed materials simply to transport it around. If the factory didn't need such massive quantities of it, trucking it in would likely be preferable.

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Now I'm imagining a procedural cop show where they bust an illegal helium dealer, and one of the cops takes a huff to gauge what they're dealing with, and then squeaks out "that's the good stuff".
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Do we have a process to make new helium from hydrogen?
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If you come up with a process to do that efficiently, the helium will be a lovely bonus but not remotely the most important result. :D
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Nuclear fusion?
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