There are a couple of minor annoyances for sure, like the car grabbing my phone when it turns on, but that's not a huge deal. And the annoyance of having a cord dangle around while I'm walking the dog or doing dishes or whatever the hell I'm doing far outweighs it.
All of that said, if I wanted audio quality to sit and actively listen to music, I'd go wired no question. But I don't really care when 95% of my listening is audiobooks and podcasts.