So for any process that's using less than 16GB, it's a significant performance boost. And most processes using more RAM, but not splitting accesses across more than 16 zones in rapid succession, will also see a performance boost.

My old Intel CPU only has 4 slots for 1GB pages, and that was enough to get me about a 20% performance boost on Factorio. (I think a couple percent might have been allocator change but the boost from forcing huge pages was very significant)