You need fast storage to make it worthwhile. PCIe x4 5.0 is a reasonable minimum. Or multiple PCIe x4 4.0 accessed in parallel, but this is challenging since the individual expert-layers are usually small. Intel Optane drives are worth experimenting with for the latter (they are stuck on PCIe 4.0) purely for their good random-read properties (quite aside from their wearout resistance, which opens up use for KV-cache and even activations).