that's kind of what P800 (notable work) is doing, but you can try some approximations to "major work" with "has both an English Wikipedia page and a Goodreads link":

  ?work wdt:P50 ?author ;
        wdt:P577 ?publicationDate ; 
        wdt:P8383 ?goodreadsID .

  ?article schema:about ?work ;
           schema:isPartOf <https://en.wikipedia.org/> ;
           schema:inLanguage "en" .