Artisanal crafts are alive and well. It turns out that some people actually prefer handmade stuff to the mass-produced kind, and there's plenty enough of them for a viable market, at least for the highest-quality producers. The real losers are those who make stuff of only barely-acceptable quality: they have no edge over what's mass produced, their middling skills lose value and they're forced to exit the sector.

For a lot of companies their entire income entirely depends on their uptime.

Might be fine if your HR software isn't approving holiday requests, but your checkout breaks, there's no human that can pick apart the mess and you lose your entire income for a week and that might be the end of the business.