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What was the reason for those protests? Was it perhaps economic hardship brought about by US sanctions? How much is the US liable for the suffering of the Iranian people?

(A lot, is the answer)

That doesn't excuse the Iranian regime, but the US is not exactly helping, is it.

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It was hardship brought on by not attempting to address the problems. Sanctions made things a bit worse but if Iran put effort into ensuring there was fresh water instead of funding terrorists and building missles things would have been a lot better for the people. (And likely no senctions for those things)
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