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There is a LOC (Loss of Crew) number that is typically calculated for these missions. I'm curious what that is? Early Apollo missions were on the order of 4%.
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Before the Apollo launch, von Braun was asked what the reliability of the rocket was. He asked 6 of his lieutenants if it was ready to fly. Each replied "nein". Von Braun reported that it had six nines of reliability.
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I'm assuming this is fake but it's hilarious.
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GitHub taking notes
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Is that a real fact?
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(I misremembered it slightly, so sue me)

From "Apollo The Race to the Moon" pg 102:

The joke that made the rounds of NASA was that the Saturn V had a reliability rating of .9999. In the story, a group from headquarters goes down to Marshall and asks Wernher von Braun how reliable the Saturn is going to be. Von Braun turns to four of his lieutenants and asks, "Is there any reason why it won't work?" to which they answer: "Nein." "Nein." "Nein." "Nein." Von Braun then says to the men from headquarters, "Gentlemen, I have a reliability of four nines."

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You know why you chose 6 9s.
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Reliability of 4 neins to be precise
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The date checks
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After the moon landing, Armstrong allowed that he had estimated the survivability at 50%.
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In 2014 an independent safety panel estimated 1:75, but I think it's slightly better now. The shuttle program officially had a limit of 1:90 but in practice achieved 1:67.
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In the early days of the Shuttle program, the probability was supposedly estimated as low as 1:100,000. Challenger brought on a more realistic approach.
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The official minimum standard is 1:270
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Hilarious!
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