Without oxidizing air, it is easier to extract metals from the Moon rocks.
There is little doubt that it would be possible to build big spaceships on the Moon.
However, what is missing on the Moon is fuel. For interplanetary spacecraft, nuclear reactors would be preferable anyway, which could be assembled there from parts shipped from Earth, but for propulsion those still need a large amount of some working gas,to be heated and ejected.
It remains to be seen if there is any useful amount of water at the poles, but I doubt that there is enough for a long term exploitation.