There are derivatives of APL, e.g. J, which replace the symbols with ASCII characters, to avoid the keyboard problem:

https://www.jsoftware.com/#/README

I actually prefer a hybrid solution, i.e. using a part of the original APL symbols, which are now provided by Unicode, so you can map them on any standard keyboard as you please, while other symbols are replaced by keywords.

The reason is that a part of the original APL symbols make sense and are useful, because they are extensions of the traditional mathematical notation, while some other symbols, e.g. those used for trigonometric functions, are arbitrary and had only the purpose to make the text somewhat shorter and simplify the parsing of the language at a very early time, when the available resources were very scarce, and this does not matter today any more.