Frankly, I'm getting tired of having to constantly "verify" this and "confirm" that every time I sign up for or log into an online service. It's especially annoying after I've already signed up. Every bank that I haven't logged into for the last 5 milliseconds hits me with a "confirm your E-mail yet again" flow. I'm going to just start using "password" for my password if these guys keep insisting on round-tripping through my E-mail every time I need to do anything.
Also, an important use is password and username recovery. We even got password or username request 30 minutes after signup! They had quiz to solve if they want to help during studding and it's good to track them.
We had a lot of wrong emails, in particular it was common someone@yahoo.com instead of someone@yahoo.com.ar because Yahoo! offer both options. Also someone@gmail.com.ar that does not exist, but that never stop users.
(If it help, we never asked to confirm the email again after the registration.)