I use MO2 on Linux through Steam's Proton runtime, to play TTW (Fallout NV mod). Works fine. The TTW installer did require an older Proton version though.

Probably not often I'd say, but at least there were some games I played with wine where some executables to apply mods also ran in wine and worked, I vaguely remember some fix to make something be able to use more than a few GB of ram to allow farther or better remdering, sometimes just a strange combination of things is needed to get something to work. But that's actually long ago, these days everything just works in Steam instead

Janky but works. I started experiment with game scope I think is called. Interesting results upscaling some games. Fiddly though