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>there can be no interstate market in a substance that is illegal to trade.

There is in fact an interstate market in many substances that are illegal to trade because laws against things do not make those things fail to exist.

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No market that the federal government can recognize, tax or regulate
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Illegal commerce is still subject to taxation and regulation, famously so in the case of Al Capone.
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Legally subject to. Practically, untaxed.
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By making it illegal, it has already been regulated. The IRS also requires reporting and taxing all income, even that which was unlawfully gained.
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The reason marijuana is Federally illegal in the first place is because the commerce clause is interpreted to allow it.
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