Interestingly, rclone supports that on many providers, but to be able to backblaze support that, it needs to integrate rclone, connect to the providers via that channel and request checks, which is messy, complicated, and computationally expensive. Even if we consider that you won't be hitting API rate limits on the cloud provider.
Sometimes modification time of a file which is not downloaded on computer A, but modified by computer B is not reflected immediately to computer A.
Henceforth, backup software running on computer A will think that the file has not been modified. This is a known problem in file synchronization. Also, some applications modifying the files revert or protect the mtime of the file for reasons. They are rare, but they're there.