The only downside is that I suspect the Framework would be a decent bit quieter under load (not that this thing is abnormally loud). As well as you're limited to a single M.2 2230 internal SSD slot in this (I believe Micron recently launched a 4 TB model, but generally you'll max out at 2 TB without using an external enclosure).
I don't have anything against the Framework, I'm sure it's a great machine, but the Z13 is an incredible portable all-in-one device that can handle everything from general PC use to gaming to tablet/entertainment to LLMs & high perf.
I put my boards in mini itx rack mounts personally so framework is the only option.
[0] https://frame.work/products/desktop-diy-amd-aimax300/configu...