Thanks, I am aware of reduced cerebrospinal fluid flushing as well as the increased neural inflammation in general and I am trying to compensate for that as best as I can.

I am not too worried about Alzheimer's as it tends to start pretty late in life (I think average onset is around mid-60s?). If I get that and we don't have a reliable cure by then, I wouldn't really mind ending it quickly after getting the diagnosis. I'm a bit more worried about heart disease as that tends to hit earlier.