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Recognizing that certain mutations very blatantly reduce a person's quality of life and making it possible to revert those mutations does not require treating the people who have not had those mutations reverted as lesser.

Thinking of them as lesser leads to a society that prefers to drag each other down instead of lifting each other up.

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I don't know about this argument because they seem a lot happier than I am.

That's not to say that it's unreasonable to value intelligence over happiness, but framing it as quality of life seems off.

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There are arguments about various "conditions" being diseases or not, Down Syndrome really isn't one of them.
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