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Primogeniture in any form is discriminatory precisely since birth order is an immutable, permanent, unchosen characteristic assigned randomly at birth, just like race or sex.
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Sex is mutable but good try
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Gender is mutable. Sex is determined by genetics, though in a handful of creatures, sex could be considered mutable.
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You're right, but there was an article on here in the last week about genetic therapy correcting Down Syndrome.

I wonder how long before sex does actually become mutable.

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You can change sex

And people can be born intersex

Your data is wrong

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