Its a bit naieve to claim that cleaning one's home will result in an extinction of enough microbes so as to be threatening to our immune system.
https://en.wikipedia.org/wiki/History_of_polio
> [...] Better hygiene meant that infants and young children had fewer opportunities to encounter and develop immunity to polio. Exposure to poliovirus was therefore delayed until late childhood or adult life, when it was more likely to take the paralytic form.[22]