As someone who did the former for a couple years, “better off” is subjective and dependent on your business model, particularly for B2B. It’s a trade off like anything else. You may get more leads, but they may convert at a lower rate. Sending at that scale also increases your risk of email deliverability problems. Trashing your domain has more impacts than you’d think. In smaller, targeted markets it even can damage your business reputation and hurt future sales if done poorly; word gets around.

If you’re targeting a million people, I wouldn’t consider that a hyper targeted attack.

But I get your point.