Can't speak for kefir; slimcc has been `make unittest`ing Neovim v0.10.4 with no source modification in a Debian VM (so it's pretty portable, thanks!)

On tcc, the most common dealbreaker is no thread local support, having independent assembler/linker is a wonderful feat but not being feature parity with binutils could lead to build failure, contributors generally less willing to support the correct behavior for ABI, C standards and GCC extensions.

I hope these don't sound like a diss, if I had been better at reading its coding style I would definitely try to contribute to mob branch.