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by justinc86876 hours ago |
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upvoteby jmalicki1 hours ago|
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In my wilderness first responder class they emphasized taking a cocktail of ibuprofen and acetaminophen - both are effective pain relievers, each with different dangerous side effects.

The benefits stack, the side effects don't.

So if you are going to be loading up on higher doses of pain relief, take half acetaminophen and half ibuprofen.

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upvoteby justinc86876 hours ago|
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P.S. like someone mentioned in a comment below happened to them, be careful with NSAIDs over the long term. Until recently I took them daily for better part of 3 years. I was recently diagnosed with chronic kidney disease. Can't definitively say causation, but they definitely contributed. They're fine for short term use but can really f$%# you up with long term, daily use.
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upvoteby vidarh6 hours ago|
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It is absolutely valid to warn about long term use, and NSAIDs in particular (I was lucky and had a gastroscopy before they'd done any serious damage, but they found significant erosion of my stomach lining due to NSAIDs), but acetaminophen/paracetamol isn't an NSAID (ibuprofen and aspirin, for example, are)
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upvoteby justinc868740 minutes ago|
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To be clear, it was nabumetone, celecoxib or meloxicam (at various times, not overlapping) for me.
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upvoteby marcogarces4 hours ago|
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In mozambique i was committed to the hospital with my liver failing after spending two weeks taking acetaminophen daily because everyone at work got sick and someone had to keep the business up (it was a bank, our IT department was very specific and only 6 people knew that job and everyone got extremely hill). After two weeks, i finally went to the hospital and I couldn't leave; spent the next two weeks fighting for my life and at some point I was told I was not going to make it. All due a simple over the counter medicine... crazy. This was 2016. To this day I still get extremely tired if I take it, so I have to choose it carefully when to take it.
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upvoteby molf3 hours ago|
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That sounds terrible! Glad you made it out alive and hopefully recovered well! Out of curiosity: how much did you take per day?
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upvoteby e404 hours ago|
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Agreed!! Here’s my trick: take 1g and set an alarm for +6 hours. If I don’t need it, fine. If I do, repeat.
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upvoteby isoprophlex6 hours ago|
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I'm not disagreeing with you or trying to be disagreeable, but how do people accidentally exceed 3-4 grams daily? That's 6-8 pills!
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upvoteby justinc868740 minutes ago|
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You are running a high fever or have a massive headache, so know you are going to max out at 4g/day. At that point, it's kind of hard to keep track of the clock.

"My head is pounding. Shit...did I take this at 3PM or 5PM? I know I took it and then fell asleep, but I can't remember when. It is now 9PM, can I take more or not?"

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upvoteby brainwad5 hours ago|
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It often happens when people take the max dose of straight paracetamol, and then also take another drug that has paracetamol in it without knowing that (e.g. a codeine/paracetamol or ibuprofen/paracetamol combination).
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upvoteby skrebbel6 hours ago|
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People who are in a lot of pain and don’t know the risks.

Rationalizations like “they probably put the limit way lower than the real limit so idiots don’t OD themselves, so I can safely take a bit more” become very attractive when you’re in a lot of pain.

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upvoteby jeroenhd4 hours ago|
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To be fair, the "real" limit depends on how lucky you are with your body's makeup. The safe limit is below that limit.

I know people with permanent pain due to medical conditions who have been given a doctor's approval to exceed the limits printed on the packaging (after having previously been monitored). You can exceed the limit on the packaging by one or two pills.

A bit more is often not deadly, but it's very easy to take more than a bit. When I had a messed up mouth for several days, I took the maximum doses and set timers to help me regulate the dosage throughout the day, but I sure wished I could've taken more at that time.

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upvoteby isoprophlex5 hours ago|
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Okay that's right, if you just keep upping the dose because you're still in pain it might be easy to just slam a few every 4 hours

From personal experience if i have a headache I'll take 1000 mg all at once; it either works right away or it doesnt and I stop bothering until I've had a good nights rest...

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upvoteby kakacik5 hours ago|
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Imagine if that rest will do nothing for that headache and its there morning day and night. Or some injury-related pain which simply can't be downtuned. Plus when old, half of the body aches, all old injuries and general deterioration.

I had only very brief experiences with longer intense pain but it made my mind into pudding and desperate knot of how-to-stop-this-at-all-costs. Normal life is not possible and sanity is not granted.

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upvoteby justinc868737 minutes ago|
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Yah...I've been there for 6 months now with a constant headache. The first month or so, I was taking 3.5g/day consistently. At hour 4.5 - 5, it would wear off. If it wasn't for my tracking, I probably would have ODed.
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upvoteby vidarh6 hours ago|
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If you take 2 on average every 4 hours, you're at 12. If you're feverish or otherwise feeling ill enough and sleep deprived enough, forgetting when you took them last is easy. Personally I write down the time I took the last one.
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upvoteby ufo1 hours ago|
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It can also happen if the person has some disease that affects the liver, which in turns lowers how much of the drug they can take.
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upvoteby mordae4 hours ago|
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Hot Coldrex (Tylenol) + Pills. People don't read.
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