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It’s actually quite simple: 1–5 mg lithium orotate, vitamin D, omega-3 from algae with high levels of polyphenols, a daily exercise routine, and good food—not the processed crap you often get in the US. My grandmother is 94 and still mentally so sharp that she amazes me every time.

https://michael-nehls.de/

by delecti43 minutes ago|

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Was she diagnosed with Alzheimers, which she then managed to halt the progress of?

by dannyw3 hours ago|

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I agree with your post and the well-studied safety of it in humans at appropriate doses :) but the study you linked is on rats; and so there’s probably another better study to link.

I experiment and take a small number of less-commonly-known supplements and those kind of studies _in itself_ should never contribute to “it’s safe for humans”.

Anecdata: my personal brain/body didn’t react too well to 1mg a day, I felt somewhat ‘sluggish’ and found concentrating harder, so I stopped after 2 days out of being conservative. Perhaps I’d get used to it, but for me personally, I was surprised at the effects of just 1mg so I didn’t want to continue taking it.

by throwaway848495 hours ago|

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Interesting. I'm also taking orotate, and like the other comment here, it makes me very sleepy (so I'm taking much less than 1mg/day). Maybe that's the brain working to "take out the trash?"

Earlier today I read a comment here mentioning Dr Michael Nehls who writes about lithium and also dementia (highly recommend his books). Now that comment is no longer there. Hmmm.

by Noaidi2 hours ago|

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Nah, lithium is only treating something that is occurring much deeper: low glucose transport in the brain.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8772148/

This is why APoE e4 alleles are a risk factor, because they control glucose transport.

https://www.nature.com/articles/s41398-025-03550-w

The brain is just losing energy.

by Mistletoe7 hours ago|

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Every time I read about it and get jazzed I take it and feel awful. I’m guessing my brain chemistry is better without it.

by cubefox1 hours ago|

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Any side effect goes away if you reduce the dosage sufficiently. In the recent Harvard study the dose was very small when you convert it to a human equivalent dose.

by rcxdude11 minutes ago|

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So does any effect as well, though.

by Mistletoe1 hours ago|

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I do try small doses.

by cubefox27 minutes ago|

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Apparently not small enough ("feel awful")

by mongol7 hours ago|

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Awful how?

by Mistletoe7 hours ago|

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My spreadsheet says it makes me feel incredibly sleepy.

by totierne26 hours ago|

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I took lithium for <redacted tendancy> it got to my kidneys never thought of more generally microdosing lithium. Interesting. Full dose yeah flat and sleepy. Not sure it was the reason for flat out brain rot. (Other factors were available maybe just getting older.) Full dose needs blood tests as overdose weirdly bad. From <relative> due to dehydration / holiday in the sun looked like almost drunk but not drinking slopy etc. Slightly clingy desparate for interaction with strangers. <Other factors could have been available>. Not informed of damage relative seemed to recover ok. <Nationalised medical system>.