In Linux, the only things I don't have with Wine are whatever the other clipboard is that highlighting text gets filled with and access to network shares. Such nothingburgers that I've never spent real time to figure out if there's a solution.
It's not the end of the world, but the Windows version of Excel is streets ahead of the macOS version, which is why I was keen to make it work.
Otherwise, everything I really care about from Windows - the odd utility, along with retro computing emulators - seems to run fine on Wine. I haven't got into more modern games so can't speak to how well they tend to run.
When someone has an issue getting something like Notepad++ running with Wine, they have the option to inform the Notepad++ project or if they possess the skills, submit a change so that Notepad++ will run smoothly on Wine. Or, inform Wine and they may figure out how to fix the issue within Wine.
I haven't bothered getting Office running on Linux in a very long time. The only thing I miss is a convenient way to print envelopes, as LibreOffice is incapable of doing this. However, I mail far less than I used to so I just hand write the addresses.
I think the only real way to run Office is on Windows in VirtualBox, which I still haven't had any need to bother with.