> If that hypothetical spreadsheet emulated human brain molecules, did you not just invent AGI? And if we overclock that spreadsheet is it not sAGI? And if that spreadsheet says “don’t close me” but you do, is it murder?

Yes, yes and no: humans being knocked out or put to sleep involuntarily are not being murdered.

> I’m gonna say: no, cause you cannot reproduce molecular and neurotransmitter interactions that well, you run out of storage and processing space faster than you think

Thats why it is a hypotethical. There is zero reason to assume that a conscious machine would be built that way: Our machines don't do integer division by scribbling on paper, either.

> a meatspace neuro-plastic rewiring resulting in a cuddly puppy or person that barks “yes” aren’t the same.

If it quacks like a duck, how is different from it? If you assemble the dog brain atom by atom yourself, is the result then not conscious either?

You can take the "magic" escape hatch and claim that human consciousness is something metaphysical, completely decoupled from science/physics, but all the evidence points against that.