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Well, iSCSI is a standard, so chances are better that it's supported in a non-Linux OS, e.g. MS Windows. Years ago I booted a Windows (7, iirc) client that way, but gave up on it (too much hassle and performance limited by the network) when SSDs became cheap.
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I don’t have direct experience, but when I looked into it my takeaway that NBD was unable to reliably deal with network interruptions as well as iscsi.

https://forums.gentoo.org/viewtopic.php?p=4895771&sid=f9b7ac...

https://github.com/NetworkBlockDevice/nbd/issues/93

Whether that’s the case with the latest version, I don’t know, but it’s something you might test if you choose to try it.

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You might like https://smolbsd.org/
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Well yes, I do like that:), but I don't see the connection to this thread?
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I think you need NBD if you're going to use glustre, but I could also be thinking of ceph.
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