The inference engines in use already include different backend building blocks optimized for different hardware.
While there are places where you can pick up some low hanging fruit for less popular platforms, there isn't a lot of room to squeeze in super optimized model-runners for specific GPU families and get much better performance. The core computations are already done by highly optimized kernels for each GPU.
There are forks of llama.cpp that have better optimizations for running on CPU architectures, but (barring maintainer disagreements) a better use of time is to target merging these improvements upstream instead of trying to make super specific model+GPU runners.
> DeepSeek made quite a splash in the AI industry by training its Mixture-of-Experts (MoE) language model with 671 billion parameters using a cluster featuring 2,048 Nvidia H800 GPUs in about two months, showing 10X higher efficiency than AI industry leaders like Meta. The breakthrough was achieved by implementing tons of fine-grained optimizations and usage of Nvidia's assembly-like PTX (Parallel Thread Execution) programming instead of Nvidia's CUDA for some functions,
https://www.tomshardware.com/tech-industry/artificial-intell...
Custom code targeting one specific hardware implementation can improve performance quite a bit.
[1] https://codegolf.stackexchange.com/questions/215216/high-thr...
Optimizing things usually means "think of a way to do the same thing with less effort".