Developers don't like mandatory sandboxing. It has to be forced on them. So you can see the difficulty of doing it in the open source community, which has for decades now had the worst security of any desktop OS platform (even Windows is better).
SELinux will stop any process in android from loading kernel modules, that’s not allowed. The android permission model as a whole is ultimately backed by SELinux.
Imagine if Linux only let you run stuff from Flatpak, and if stuff didn't work in Flatpak then too bad for you. Most Linux users would hate it and it would be a mess a lot of the time, so, for user experience (UX) reasons, they don't do it. Android can get away with it because that's been the app paradigm for decades now.