There's a great read about the whole area here: https://www.amazon.com/Internet-Alley-Technology-1945-2005-I...
As for AWS, I often see it repeated that the DCs are the oldest and therefor in disrepair. That's not true; many of the first ones have since been replaced. But there are services that are located here and only here.
But I'll also add, a lot of customers default to using US-East-1 without considering others, and too many deploy in only one AZ. Part of this is AWS's fault as their new services often launch in US-East-1 and West-2 first, so customers go to East-1 to get the new features first.
Speaking as one who was with AWS for 10 years as a TAM and Well-Architected contributor, I saw a lot of customers who didn't design with too much resiliency in mind, and so they get adversely affected when east-1 has an issue (either regional or AZ). The other regions have their fair bit of issues as well. It's not so much that east-1 necessarily fails more than the others, it's that it has so many AZs and so many workloads that people notice it more.
Why is that? You would think the company ending events like IAM going poof due to it being dependent on us-east-1 would be top priority to fix?
If you're building a single datacenter site this is where you start building first.