Mind you: that's on one of the most convulated ways there is to get involved, because it involves a bunch of smart contract operations and on-chain voting. If we are talking about crypto only as a payment network, things are even simpler.
A generic python library used by generic people who have no interest in this field is something else.
Also, we are talking about people who are tech-savvy enough to be interested in participating in a FOSS project. Opening an account at an exchange is not rocket science.
And those who are living in countries the USA doesn't like will probably have no issue to learn how to work with crypto. Of all the complex things they need to do to work around the restrictions, setting up a wallet barely registers.