If you've read any Vatican publications, the theme is being the authority on the ontology of reality.
EDIT: A decree for bioethics https://www.vatican.va/roman_curia/congregations/cfaith/docu... I'd expect a similar deal for AI.
-- Guards! Guards! by Terry Pratchett
(Yeah, it’s a problem, but they can’t see it)
“Robert Mueller just died. Good, I’m glad he’s dead. He can no longer hurt innocent people!”
The Pope has already spoken quite a bit about ai, and exhorted priests to keep ai out of their homilies, which should be a sacred fruit of prayer and study.
Just from what I have seen he said and my Catholic Theological background, I would say he will definitely be talking about at least a couple things: 1) the relationship between ai and our intellectual labor, and how to use it fruitfully to grow without losing ourselves in it (a very similar concern to many on hn as far as I understand); and more importantly for him and again for many 2) how to use ai in society in a way that everybody can enjoy the fruits of it, instead of just the elite few (similar to the priority of Rerum novarum). This Pope chose his name because of this theme, and has consistently demonstrated that social justice is amongst his highest priority concerns - to the point that he has asked the Church to stop focusing so heavily on sexual ethics because there are such weighty injustices in the world that require our focused effort and attention.
For the shrinking Catholic church it's trying to regain relevance. For Anthropic it's PR.