You can lower that to at least 24GB. I've been running Qwen 3.5 and 3.6 with codex on a 7900 XTX and the long horizon tasks it can handle successfully has been blowing my mind. I would seriously choose running my current local setup over (the SOTA models + ecosystem) of a year ago just based on how productive I can be.
DeepSeek V4 Pro likewise is insanely good for the price. I simply point it at large codebases, go get a cup of coffee or browse Hacker News, and then it's done useful work. This was simply not possible with other models without hitting budget problems.
People report good results from DeepSeek V4 Flash at 2 bits (the DwarfStar 4 folks are doing it, and I've tried it on my Strix Halo, but it's too slow to be usable, so I haven't bothered to figure out if it's actually smart enough to use for anything).
Anyway, it's obvious models have to degrade in terms of knowledge, at any quantization, even though it may not show up clearly on benchmarks until lower. If you halve the size of the data available, it necessarily loses information about the world.